Evidence for the involvement of neuropeptide Y in the antidepressant effect of imipramine in type 2 diabetes

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Evidence for the involvement of neuropeptide Y in the antidepressant effect of imipramine in type 2 diabetes

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作者：Kartik T. Nakhate^a ; ¹ ; Sadanand U. Yedke^b ; ¹ ; Ashish P. Bharne^b ; Nishikant K. Subhedar^c ; Dadasaheb M. Kokare^b ; ^{kokaredada@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
关键词：3V ; third ventricle ; ac ; anterior commissure ; aca ; anterior part anterior commissure ; AcbC ; nucleus accumbens core ; AcbSh ; nucleus accumbens shell ; acp ; posterior part anterior commissure ; ANOVA ; analysis of variance ; ARC ; hypothalamic arcuate nucleus ; AUC ; area under the curve ; BIBP3226 ; N2-diphenylacetyl-N- [(4-hydroxy-phenyl)-methyl]-d-arginine amide ; aCSF ; artificial cerebrospinal fluid ; BLA ; anterior part of basolateral amygdaloid nucleus ; BNSTl ; lateral division of the bed nucleus of stria
刊名：Brain Research
出版年：2016
出版时间：1 September 2016
年：2016
卷：1646
期：Complete
页码：1-11
全文大小：2161 K

文摘

•: Depression is a major comorbidity factor of diabetes.
•: Type 2 diabetes reduces NPY expression in extended amygdala.
•: NPY attenuates type 2 diabetes induced depression.
•: NPY mediates antidepressant effect of imipramine in diabetic mice.

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