Type I/type III collagen ratio associated with diverticulitis of the colon in young patients

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• 作者：Shaun R. Brown ; DO^a ; ^{srbrowndo@gmail.com} ; Elane M. Cleveland ; MD^a ; Corey R. Deeken ; PhD^b ; Sonni S. Huitron ; DO^c ; Kanayochukwu J. Aluka ; MD^a ; Kurt G. Davis ; MD^a
• 关键词：Diverticulitis ; Collagen ratio ; Type I collagen ; Type III collagen
• 刊名：Journal of Surgical Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：207
• 期：Complete
• 页码：229-234
• 全文大小：1032 K
• 卷排序：207

文摘

The incidence of diverticulitis in young patients is rising, whereas the type I:III collagen ratio of the colon decreases with age. Perhaps a lower type I:III collagen ratio in younger patients may predispose these patients to the development of the disease.MethodThe purpose of this study was to evaluate the collagen content and type I:III collagen ratio in patients with diverticulitis versus a control group. Patients who underwent a colon resection were identified. Three groups of patients were created for analysis: those with diverticulitis aged <50 y, >50 y, and a control group. Tissue samples were stained with Sirius red/fast green and photographed. Photos analysis was performed to quantify the amount of type I collagen and type III collagen. The type I:III collagen ratio was calculated for each patient and compared.ResultsThe quantity of type I collagen and type III collagen was higher in patients with diverticulitis aged >50 y (P = 0.04 and P < 0.0001, respectively); however, the collagen ratio was greatest in those patients with diverticulitis aged <50 y (P = 0.01). Further analysis demonstrated a significant higher type I:III ratio in all patients aged less than 50 y compared with all patients aged over 50 y (P = 0.04).ConclusionsOur study demonstrated that diverticulitis in the younger patient was not associated with a lower type I:III collagen ratio. It appears that the decrease in collagen ratio of the colon with age is associated with an increase in type III collagen deposition.