Chronic granulomatous lung infection caused by the dimorphic fungus Emmonsia sp.

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• 作者：Nele Wellinghausen ; Winfried V. Kern ; Gerhard Haase ; Eva Rozdzinski ; Peter Kern ; Reinhard Marre ; Andreas Essig ; Jü ; rgen Hetzel ; Martin Hetzel
• 关键词：Emmonsia ; adiaspiromycosis ; granuloma ; itraconazole
• 刊名：International Journal of Medical Microbiology
• 出版年：2003
• 出版时间：2003
• 年：2003
• 卷：293
• 期：6
• 页码：441-445
• 全文大小：85 K

文摘

A 64-year old farmer developed cough, dyspnoea on exertion, and recurrent febrile episodes. X-ray and CT scan revealed bilateral lower lobe opacities in his lungs. A transbronchial biopsy was performed and histopathological findings were interpreted as consistent with a pulmonary necrotizing clear-cell carcinoma and later as a Pneumocystis carinii pneumonia. Due to persistence of symptoms, six months later another lung biopsy was performed and a mould was cultured which was identified by 18S rDNA sequencing as Emmonsia sp. The patient showed some improvement under itraconazole treatment. This is the first description of a human infection with Emmonsia sp. in Germany.