Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity

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Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity

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作者：Simone Hettmer^a ; ^b ; ^c ; ^{simone.hettmer@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author} ; Michael M. Lin^a ; ^b ; Daria Tchessalova^a ; ^b ; Sara J. Tortorici^a ; ^b ; Alessandra Castiglioni^a ; ^b ; Tushar Desai^d ; Junhao Mao^e ; Andrew P. McMahon^f ; Amy J. Wagers^a ; ^b
关键词：FAP ; fibroadipogenic progenitors ; PAX7 ; paired box 7 ; MRF ; myogenic regulatory factor ; Hh ; Hedgehog ; MyoD1 ; myogenic differentiation 1 ; Smo ; Smoothened ; Gli1 ; Gli family zinc finger 1 ; Ptch1 ; Patched 1 ; rRNA ; ribosomal ribonucleic acid ; CAGGS ; CMV early enhancer/chicken beta actin ; ER ; estrogen receptor ; FABP4 ; fatty acid binding protein 4 ; DMEM ; Dulbecco's Modified Eagle Medium ; DM ; differentiation medium ; CM ; conditioned medium ; HBSS ; Hank's Balanced Salt Solution ; FBS ; fetal bovine serum ; bFG
刊名：Experimental Cell Research
出版年：2016
出版时间：1 January 2016
年：2016
卷：340
期：1
页码：43-52
全文大小：6202 K

文摘

•: Hedgehog activation induces multifocal tumors in skeletal muscle.
•: These tumors recapitulate skeletal muscle phenotypic and functional heterogeneity.
•: They contain cells with differential myogenic and adipogenic capacity.
•: Hedgehog activation enhances satellite cell differentiation.

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