Effects of interaction CdZn on serum-PSA level and prostate histology in rats

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• 作者：Abdelkrim Berroukche¹ ; ^{kerroum1967@yahoo.fr} ; Mohamed Terras¹ ; Abdelrahmane Labani¹ ; Hafsa Dellaoui² ; Wassila Lansari²
• 关键词：Cadmium ; Zinc ; PSA ; Hyperplasia
• 刊名：Asian Pacific Journal of Tropical Biomedicine
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：7
• 期：3
• 页码：245-248
• 全文大小：780 K
• 卷排序：7

文摘

To assess cadmium sulfate (CdSO4) and zinc chloride (ZnCl2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats.MethodsThe study included 40 adult male rats, divided into four groups: Group 1 (CdSO4), Group 2 (ZnCl2), Group 3 (CdSO4ZnCl2) and Group 4 (control). Animals were treated with CdSO4 and ZnCl2 at the same dose (15 mg/L) during 30 days.ResultsIt was showed a higher body weight and a lowering serum-prostate specific antigen concentration [(1.8 ± 0.6) ng/mL] in animals treated with CdSO4. CdSO4 induced a cyto-nuclear atypia, proliferative lesions, hyperplasia and precancerous foci in prostate tissue. Toxic effects of ZnCl2 were not recorded in this study.ConclusionsProtective role of zinc was exhibited against toxic effects of cadmium in prostate gland.