Bone marrow transdifferentiation in brain after transplantation: a retrospective study

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• 作者：Cogle ; Christopher R ; Yachnis ; Anthony T ; Laywell ; Eric D ; Zander ; Dani S ; Wingard ; Prof John R ; et. al.
• 刊名：The Lancet
• 出版年：2004
• 出版时间：May 1, 2004
• 年：2004
• 卷：363
• 期：9419
• 页码：1432-1437
• 全文大小：1.97 M

文摘

Background End-organ repair by adult haemopoietic stem cells is under great scrutiny with investigators challenging the notion of these cells’ plasticity. Some investigations of animals and short-term human bone marrow transplants suggest that bone marrow can repair brain. We looked for evidence of clinically relevant marrow-derived restorative neurogenesis: long-term, multilineage, neural engraftment that is not the result of cell-fusion events.