Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity

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• 作者：Yu-Zhi Fu¹ ; Shan Su² ; Yi-Qun Gao¹ ; Pei-Pei Wang² ; Zhe-Fu Huang³ ; Ming-Ming Hu² ; Wei-Wei Luo² ; Shu Li¹ ; Min-Hua Luo³ ; Yan-Yi Wang³ ; Hong-Bing Shu¹ ; ² ; ⁴ ; ^{shuh@whu.edu.cn}
• 关键词：HCMV ; cGAS ; STING ; MITA ; UL82 ; immune evasion ; iRhom2 ; innate immunity ; virus
• 刊名：Cell Host & Microbe
• 出版年：2017
• 出版时间：8 February 2017
• 年：2017
• 卷：21
• 期：2
• 页码：231-243
• 全文大小：3917 K
• 卷排序：21

文摘

HCMV tegument protein UL82 negatively regulates STING-mediated signaling UL82 inhibits cellular trafficking of STING by disrupting its translocation complex UL82 also impairs the recruitment of TBK1 and IRF3 to the STING complex UL82 deficiency promotes host antiviral response and inhibits HCMV replication