A direct thrombin inhibitor suppresses protein C activation and factor Va degradation in human plasma: Possible mechanisms of paradoxical enhancement of thrombin generation

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A direct thrombin inhibitor suppresses protein C activation and factor Va degradation in human plasma: Possible mechanisms of paradoxical enhancement of thrombin generation

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作者：Chikako Kamisato ; Taketoshi Furugohri ; Yoshiyuki Morishima ; ^{morishima.yoshiyuki.t4@daiichisankyo.co.jp" class="auth_mail" title="E-mail the corresponding author}
关键词：aPC ; activated PC ; aPC-PCI ; activated PC-PC inhibitor complex ; AT ; antithrombin ; AUC0-TTP ; area under the curve of integrated intensity from the start of TG to time to peak ; FVa ; factor Va ; FVaHC ; FVa heavy chain ; FVa307&ndash ; 506 ; FVa degradation product ; FVIIIa ; factor VIIIa ; FXa ; factor Xa ; IIai ; active site-blocked thrombin ; PC ; protein C ; SEM ; standard error of the mean ; TF ; tissue factor ; TG ; thrombin generation ; TM ; thrombomodulin
刊名：Thrombosis Research
出版年：2016
出版时间：May 2016
年：2016
卷：141
期：Complete
页码：77-83
全文大小：1843 K

文摘

•: A direct thrombin inhibitor melagatran enhanced thrombin generation (TG) in plasma.
•: Melagatran inhibited protein C (PC) activation at the same concentrations.
•: Dabigatran and active site-blocked thrombin showed similar effects to melagatran.
•: Melagatran suppressed factor Va degradation and subsequently increased factor Va.
•: Inhibition of PC activation/increase in factor Va may cause TG enhancement.