CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain

详细信息    查看全文

• 作者：Ryosuke Takaya^a ; Jun Nagai^a ; ^b ; Wenfui Piao^a ; Emi Niisato^a ; Takeru Nakabayashi^a ; Yuki Yamazaki^a ; Fumio Nakamura^c ; Naoya Yamashita^c ; Papachan Kolattukudy^d ; Yoshio Goshima^c ; Toshio Ohshima^a ; ^{ohshima@waseda.jp}
• 关键词：ANOVA ; analysis of variance ; CA1 ; cornu ammonis 1 ; Cdk ; cyclin dependent kinase ; CNS ; central nervous system ; CRMP ; collapsin response mediator protein ; CRMP2ki/ki ; CRMP2 knock-in ; EDTA ; ethylenediaminetetraacetic acid ; GFP ; green fluorescent protein ; GSK ; glycogen synthase kinase ; MAIs ; myelin-associated inhibitors ; O/N ; overnight ; PFA ; paraformaldehyde ; RT ; room temperature ; Sema3A ; semaphorin3A ; WT ; wild-type
• 刊名：Brain Research
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：1655
• 期：Complete
• 页码：161-167
• 全文大小：1102 K
• 卷排序：1655

文摘

Altered dendritic orientation of layer V neuron in cerebral cortex in Crmp4−/− mice. Co-deletion of CRMP1 and CRMP4 induced severer phenotypes in dendritic development. CRMP1 and CRMP4 have redundant function of dendritic development of cortical neuron.