Mycoloyltransferases: A large and major family of enzymes shaping the cell envelope of Corynebacteriales

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• 作者：Nathalie Dautin^a ; Cé ; lia de Sousa-d'Auria^a ; Florence Constantinesco-Becker^a ; Cé ; cile Labarre^a ; Jacques Oberto^b ; Ines Li de la Sierra-Gallay^c ; Christiane Dietrich^a ; Hanane Issa^a ; ^d ; Christine Houssin^a ; ^{christine.houssin@i2bc.paris-saclay.fr} ; Nicolas Bayan^a ; ^{nicolas.bayan@i2bc.paris-saclay.fr}
• 关键词：aa ; amino acids ; AG ; arabinogalactan ; Ag85 ; antigen 85 ; DEP ; diethyl phosphate ; DTT ; dithiothreitol ; ESI-MS ; ElectroSpray Ionisation- Mass Spectrometry ; Fbp(s) ; fibronectin-binding protein(s) ; FITC ; fluorescein isothiocyanate ; HTS ; high throughput screening ; INH ; isoniazid ; mAGP ; mycolic acid-arabinogalactan- peptidoglycan ; Mar ; multiple antibiotic resistance ; (c ; r)Myt(s) ; (Corynebacterium ; Rhodococcus) mycoloyltransferase(s) ; PG ; peptidoglycan ; RMSD ; rootmean square deviation ; RND ; resistance-n
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3581-3592
• 全文大小：1261 K
• 卷排序：1861

文摘

Mycoloyltransferases are key players in the biogenesis of Corynebacteriales envelope. They transfer mycolates on sugars or proteins by a ping-pong mechanism. The number of Myt paralogs in most Corynebacteriales varies between 3 and 9. Myt are partially redundant but may also play specific roles in vivo. Myt might be secreted through the inner membrane by different mechanisms.