Pannexin1 as mediator of inflammation and cell death

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• 作者：Sara Crespo Yanguas^a ; ¹ ; Joost Willebrords^a ; ¹ ; Scott R. Johnstone^b ; Michaë ; l Maes^a ; Elke Decrock^c ; Marijke De Bock^c ; Luc Leybaert^c ; Bruno Cogliati^d ; ² ; Mathieu Vinken^a ; ² ; ^{mvinken@vub.ac.be}
• 关键词：ASC ; apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain ; ATP ; adenosine-5&prime ; -triphosphate ; [Ca2  ; +]i ; intracellular calcium concentration ; CARD ; caspase activation and recruitment domain ; CT ; carboxyterminal ; Cx ; connexin ; DAMP(s) ; damage-associated molecular pattern(s) ; HIV ; human immunodeficient virus ; IL1α/1β/2/17/18 ; interleukin1 alpha ; 1 beta ; 2 and 18 ; LPS ; lipopolysaccharide ; NF-κB ; nuclear factor kappa beta ; NLR ; nucleotide-binding oligomer
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1864
• 期：1
• 页码：51-61
• 全文大小：1325 K
• 卷排序：1864

文摘

Pannexin1 channels permeate ions and molecules in the size range of 1.5 kDa. Pannexin1 channels are identified as ATP release channels as well as anion selective-channels. Pannexin1 channels drive inflammation by assisting in the activation of inflammasomes, the release of pro-inflammatory cytokines, and the activation and migration of leukocytes. Pannexin1 channels facilitate cell death, including apoptosis, pyroptosis and autophagy. Pannexin1 channels inhibition or activation is an attractive potential therapeutic target in a variety of diseases.