The toll-like receptor 3 pathway in homeostasis, responses to injury and wound repair

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• 作者：Divya Ramnath^a ; ^b ; ^c ; Elizabeth E. Powell^d ; ^e ; Glen M. Scholz^f ; ^g ; Matthew J. Sweet^a ; ^b ; ^c ; ^{m.sweet@imb.uq.edu.au}
• 关键词：BBB ; blood brain barrier ; Bcl2 ; B-cell CLL/lymphoma 2 ; CNS ; Central nervous system ; CXCL ; C-X-C motif ligand ; EBI3 ; Epstein-Barr virus induced gene 3 ; FADD ; Fas-associated death domain ; HBV ; Hepatitis B virus ; HSC ; Hepatic stellate cell ; HSV ; Herpes simplex virus ; I/R ; Ischemia reperfusion ; IAV ; Influenza A virus ; IEC ; Intestinal epithelial cell ; IFN ; Interferon ; IL ; Interleukin ; IRF ; Interferon regulatory factor ; MAL ; MyD88 adaptor-like ; MAPK ; Mitogen-activated protein kinase ; MyD88 ; Myeloid di
• 刊名：Seminars in Cell & Developmental Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：61
• 期：Complete
• 页码：22-30
• 全文大小：2918 K
• 卷排序：61

文摘

In addition to their established roles in host defence, Toll-like Receptors (TLRs) have emerging roles in control of homeostasis, injury and wound repair. The dsRNA-sensing receptor, TLR3, has been particularly implicated in such processes in several different tissues including the skin, intestine and liver, as well as in the control of reparative mechanisms in the brain, heart and kidneys, following ischemia reperfusion injury. In this review, we provide an overview of TLR3 signalling and functions in inflammation, tissue damage and repair processes, as well as therapeutic opportunities that may arise in the future from knowledge of such pathways.