The treatment of clopidogrel resistance: Triple antiplatelet therapy and future directions

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• 作者：Sadik Acikel ; Ramazan Akdemir ; Goksel Cagirci ; Asuman Bicer Yesilay ; Mehmet Dogan ; Harun Kilic
• 关键词：Clopidogrel resistance ; Cilostazol ; Antiplatelet therapy
• 刊名：International Journal of Cardiology
• 出版年：2010
• 出版时间：24 September 2010
• 年：2010
• 卷：144
• 期：1
• 页码：79-82
• 全文大小：84 K

文摘

Despite the clinical benefit achieved with the adjunct of clopidogrel in percutaneous coronary intervention, a considerable number of patients continue to have cardiovascular events. There are accumulating evidences that recurrence of ischemic complications may be attributed to poor response to clopidogrel. However, current therapeutic alternatives for treatment of clopidogrel resistance remain limited. More aggressive intervention with higher doses of clopidogrel and the use of newer antiplatelet agents may help overcome resistance to antiplatelet agents.