Enteroendocrine cells are a potential source of serum autotaxin in men

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Enteroendocrine cells are a potential source of serum autotaxin in men

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作者：Ruth Bolier^a ; Dagmar Tolenaars^a ; Andreas E. Kremer^b ; Job Saris^a ; Albert Paré ; s^d ; Joanne Verheij^c ; Piter J. Bosma^a ; Ulrich Beuers^a ; Ronald P.J. Oude Elferink^a ; ^{r.p.oude-elferink@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author}
关键词：5-HT ; serotonin ; AD ; atopic dermatitis ; ATX ; autotaxin ; ALT ; alanine transaminase ; ALP ; alkaline phosphatase ; ANOVA ; analysis of variance ; AST ; aspartate transaminase ; AUC ; area under the curve ; CA ; cholic acid ; BAT ; brown adipose tissue ; BDL ; bile duct ligation ; CCK ; cholecystokinin ; cDNA ; complementary deoxyribonucleic acid ; CgA ; chromogranin A ; DCLK1 ; double cortin-like kinase 1 ; EEC ; enteroendocrine cell ; ELISA ; enzyme-linked immunosorbent assay ; ENPP2 ; ectonucleotide pyrophosphatase/phospho
刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年：2016
出版时间：April 2016
年：2016
卷：1862
期：4
页码：696-704
全文大小：1368 K

文摘

•: During cholestasis ATX protein content rather than enzymatic activity increases.
•: Cholestasis did not affect rATX clearance in mice.
•: ATX is expressed in human but not murine intestinal enteroendocrine cells.
•: In cholestatic mice, ATX activity is only moderately increased compared to humans.

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