Autoimmune spread to myelin is associated with experimental autoimmune encephalomyelitis induced by a neuronal protein, β-Synuclein

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• 作者：Neta Kela-Madar ; Nicole Kerlero de Rosbo ; Ayal Ronen ; Felix Mor ; Avraham Ben-Nun
• 关键词：Autoimmunity ; Autoantibodies ; T cells ; Antigens/peptides/epitopes ; Rodent
• 刊名：Journal of Neuroimmunology
• 出版年：2009
• 出版时间：31 March 2009
• 年：2009
• 卷：208
• 期：1-2
• 页码：19-29
• 全文大小：1026 K

文摘

Accumulating evidence suggests that autoimmunity against neuronal proteins is important for MS pathogenesis. We have characterized T- and B-cell responses associated with experimental autoimmune encephalomyelitis (EAE) induced in Lewis rats with recombinant β-Synuclein (βSync), a neuronal component. The encephalitogenic βSync-specific T cells recognize a single immunodominant region with an epitope delineated at amino acids 97–105; B-cell specificity is more widespread, albeit directed mostly to the C-terminus of βSync. Most interestingly, βSync-induced autoimmune T- and B-cell responses spread not only to other neuronal antigens but also to myelin encephalitogens, raising the possibility that anti-neuronal immune attacks could also result in demyelination.