What surgical treatment has the lowest recurrence rate following the management of keratocystic odontogenic tumor?: A large systematic review and meta-analysis

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• 作者：Essam Ahmed Al-Moraissi<sup>asup><sup> ; sup><sup>dressamalmoraissi@gmail.comsup> ; Ayed Ali Dahan<sup>bsup> ; Mohamed Salah Alwadeai<sup>csup> ; Fadekemi Olufunmilayo Oginni<sup>dsup> ; Jamil Mohammed Al-Jamali<sup>esup> ; Ahmed Saleh Alkhutari<sup>asup> ; Nashwan Hamid Al-Tairi<sup>asup> ; Abdulrazaq Ahmed Almaweri<sup>fsup> ; Jaber Saleh Al-Sanabani<sup>fsup>
• 关键词：Keratocystic odontogenic tumor ; Carnoy's solution ; Cryotherapy ; Resection ; Recurrence rate ; Meta-analysis
• 刊名：Journal of Cranio-Maxillofacial Surgery
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：45
• 期：1
• 页码：131-144
• 全文大小：2116 K
• 卷排序：45

文摘

This study is a largest meta-analysis, it includes 2287 non-syndromic KOTs enrolled in 35 studies. The recurrence rate (RR) for various treatment techniques was enucleation alone (23.1%), enucleation and curettage (17.4%), enucleation and Carnoy's solution (11.5%), enucleation plus liquid nitrogen cryotherapy (14.5%), marsupialization alone (32.3%), decompression followed by residual cystectomy (14.6%) and resection (8.4%). The overall RR of KOTs for all different treatments was 16.6%. To get the least chance of recurrence, enucleation with Carnoy's solution should be the first-line treatment for primary KOTs. Also, marsupialization should be followed by secondary enucleation. Finally, resections should be reserved for multiple recurrences and syndromic lesions.