Conjugate addition of amines to chiral 3-aziridin-2-yl-acrylates

详细信息    查看全文

• 作者：Doo-Ha Yoon ; Hyun-Joon Ha ; Bong Chan Kim ; Won Koo Lee
• 关键词：Conjugate addition ; Amine ; Aziridin-2-yl-acrylates ; Diamine
• 刊名：Tetrahedron Letters
• 出版年：2010
• 出版时间：21 April 2010
• 年：2010
• 卷：51
• 期：16
• 页码：2181-2183
• 全文大小：276 K

文摘

Conjugate addition of benzylamine to chiral methyl cis-3-aziridin-2-yl-acrylates was successfully proceeded to yield 3-aziridin-2-yl-3-benzylaminopropionates in high yield with high stereoselectivity. The addition products were used for the asymmetric synthesis of vicinal diamine derivatives including 4-amino-5-methylpyrrolidin-2-one, 3,4-diaminopentanoate, and 5-chloromethyl-4-alkoxycarbonylmethylimidazolidin-2-one.