Recent investigations into pig antigen and anti-pig antibody expression

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Recent investigations into pig antigen and anti-pig antibody expression

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作者：Guerard W. Byrne^a ; ^b ; ^{guerard.byrne@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; ^{schumacher.karen@mayo.edu" class="auth_mail" title="E-mail the corresponding author} ; Christopher G.A. McGregor^a ; ^b ; Michael E. Breimer^c
关键词：Xenotransplantation ; Antigen ; Antibody ; Non-Gal
刊名：International Journal of Surgery
出版年：2015
出版时间：November 2015
年：2015
卷：23
期：part_PB
页码：223-228
全文大小：631 K

文摘

•: Gal-free GTKO pigs have significantly altered xenograft rejection which is now directed to non-Gal antigens.
•: Data on human non-Gal antibody responses to pig tissue is rare, but, shows variable induction of anti-Neu5Gc antibody.
•: Nonhuman primates do not make anti-Neu5Gc antibody so the pathogenicity of this specificity remains unknown.
•: Nonhuman primates induce antibody to pig EC proteins and an Sd^a-like glycan made by porcine B4GALNT2.

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