In silico functional annotation of a hypothetical protein from Staphylococcus aureus

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• 作者：P. Bharat Siva Varma<sup>asup> ; Yesu B. Adimulam<sup>bsup><sup> ; sup><sup>yesubabuadimulam9@gmail.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Subrahmaniam Kodukula<sup>csup>
• 关键词：Hypothetical protein ; Blast ; HHpred ; Domains of unknown function
• 刊名：Journal of Infection and Public Health
• 出版年：2015
• 出版时间：November-December 2015
• 年：2015
• 卷：8
• 期：6
• 页码：526-532
• 全文大小：2555 K

文摘

Unknown proteins or hypothetical proteins exist but have not been characterized or linked to known genes. Domains of unknown function are experimentally identified proteins with no known functional or structural domain. In this paper, the investigation and characterization of the likely functional aspects of a hypothetical protein, YP_001317347.1, from Staphylococcus aureus was performed using various computational methods and tools. Based on the analysis, the protein has a YbbR domain and is expected to bind ribosomal subunits. The analysis reported here helps in understanding the importance of YbbR domains and will aid in the development of novel antibacterial agents.