Immunosuppression in cardiac graft rejection: A human in vitro model to study the potential use of new immunomodulatory drugs

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• 作者：Clara Crescioli ; Roberta Squecco ; Lorenzo Cosmi ; Mariangela Sottili ; Stefania Gelmini ; Elisa Borgogni ; Erica Sarchielli ; Sabino Scolletta ; Fabio Francini ; Francesco Annunziato ; Gabriella Barbara Vanne
• 关键词：Cardiomyocytes ; CXCL10 ; Allograft rejecton ; Immunosuppressors
• 刊名：Experimental Cell Research
• 出版年：2008
• 出版时间：1 April 2008
• 年：2008
• 卷：314
• 期：6
• 页码：1337-1350
• 全文大小：2204 K

文摘

CXCL10–CXCR3 axis plays a pivotal role in cardiac allograft rejection, so that targeting CXCL10 without inducing generalized immunosuppression may be of therapeutic significance in allotransplantation. Since the role of resident cells in cardiac rejection is still unclear, we aimed to establish reliable human cardiomyocyte cultures to investigate Th1 cytokine-mediated response in allograft rejection. We used human fetal cardiomyocytes (Hfcm) isolated from fetal hearts, obtained after legal abortions.