Effect of co-administration of memantine and sertraline on the antidepressant-like activity and brain-derived neurotrophic factor (BDNF) levels in the rat brain

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• 作者：Meysam Amidfar^a ; ¹ ; ^{amidfar.m@gmail.com} ; Gislaine Z. Ré ; us^b ; ¹ ; Joã ; o Quevedo^b ; ^c ; ^d ; ^e ; Yong-Ku Kim^f ; Mohammad Arbabi^g
• 关键词：MDD ; major depressive disorder ; NMDA ; N-methyl-d-aspartate ; BDNF ; brain-derived neurotrophic factor ; ELISA ; enzyme-linked immunosorbent assay
• 刊名：Brain Research Bulletin
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：128
• 期：Complete
• 页码：29-33
• 全文大小：627 K
• 卷排序：128

文摘

Sertraline combined with memantine induced a more pronounced antidepressant activity. Sertraline combined with memantine increased BDNF levels in the brain. In drug-resistant patients sertraline combine with memantine could be an alternative.