The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

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The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

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作者：Elizabeth C. Townsend¹ ; ³¹ ; Mark A. Murakami¹ ; ³¹ ; Alexandra Christodoulou¹ ; Amanda L. Christie¹ ; Johannes K&ouml ; ster¹ ; ² ; Tiffany A. DeSouza¹ ; Elizabeth A. Morgan³ ; Scott P. Kallgren⁴ ; Huiyun Liu¹ ; Shuo-Chieh Wu¹ ; Olivia Plana¹ ; Joan Montero¹ ; Kristen E. Stevenson⁵ ; Prakash Rao² ; Raga Vadhi² ; Michael Andreeff²¹ ; Philippe Armand¹ ; Karen K. Ballen⁶ ; Patrizia Barzaghi-Rinaudo⁸ ; ⁹ ; Sarah Cahill¹ ; Rachael A. Clark⁷ ; Vesselina G. Cooke⁸ ; ⁹ ; Matthew S. Davids¹ ; Daniel J. DeAngelo¹ ; David M. Dorfman³ ; Hilary Eaton¹⁰ ; Benjamin L. Ebert¹¹ ; Julia Etchin²³ ; Brant Firestone⁸ ; ⁹ ; David C. Fisher¹ ; Arnold S. Freedman¹ ; Ilene A. Galinsky¹ ; Hui Gao⁸ ; ⁹ ; Jacqueline S. Garcia¹ ; Francine Garnache-Ottou¹² ; Timothy A. Graubert⁶ ; Alejandro Gutierrez¹³ ; ²³ ; Ensar Halilovic⁸ ; ⁹ ; Marian H. Harris²⁹ ; Zachary T. Herbert¹⁴ ; Steven M. Horwitz¹⁵ ; Giorgio Inghirami¹⁶ ; Andrew M. Intlekoffer¹⁵ ; Moriko Ito⁸ ; ⁹ ; Shai Izraeli¹⁷ ; Eric D. Jacobsen¹ ; Caron A. Jacobson¹ ; Sé ; bastien Jeay⁸ ; ⁹ ; Irmela Jeremias¹⁸ ; ¹⁹ ; Michelle A. Kelliher²⁰
刊名：Cancer Cell
出版年：2016
出版时间：11 April 2016
年：2016
卷：29
期：4
页码：574-586
全文大小：3696 K

文摘

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PRoXe is an open-source repository of leukemia and lymphoma xenografts

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PDXs capture transcriptional, genetic, and phenotypic disease diversity

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Randomized phase II-like preclinical drug trials are feasible using PDXs

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PDXs facilitate biomarker development and testing of relapsed/refractory disease

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