Unbiased pro-thrombotic features at diagnosis in 977 thrombocythemic patients with Philadelphia-negative chronic myeloproliferative neoplasms

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Unbiased pro-thrombotic features at diagnosis in 977 thrombocythemic patients with Philadelphia-negative chronic myeloproliferative neoplasms

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作者：Luigi Gugliotta^a ; ^{luigi.gugliotta@unibo.it" class="auth_mail" title="E-mail the corresponding author} ; Alessandra Iurlo^b ; Gabriele Gugliotta^a ; Alessia Tieghi^c ; Giorgina Specchia^d ; Gianluca Gaidano^e ; Potito R. Scalzulli^f ; Elisa Rumi^g ; Alfredo Dragani^h ; Vincenzo Martinelliⁱ ; Cristina Santoro^j ; Maria Luigia Randi^k ; Giuseppe Tagariello^l ; Anna Candoni^m ; Daniele Cattaneo^b ; Alessandra Ricco^d ; Raffaele Palmieriⁿ ; Marina A. Liberati^o ; Maria Langella^p ; Angela Rago^q ; Micaela Bergamaschi^r ; Paola Monari^s ; Rossella Miglio^s ; Umberto Santoro^t ; Rossella Cacciola^u ; Serena Rupoli^v ; Lucia Mastrullo^w ; Pellegrino Musto^x ; Maria Gabriella Mazzucconi^j ; Marco Vignetti^j ; Agostino Cortelezzi^b ; Nicola Vianelli^a ; Bruno Martino^y ; Valerio De Stefano^z ; Francesco Passamonti^A ; Alessandro M. Vannucchi^B ; for the Registro Italiano Trombocitemie RIT¹
关键词：Thrombocythemia ; Thrombosis ; Platelets ; Leukocytes ; Hematocrit ; JAK2
刊名：Leukemia Research
出版年：2016
出版时间：July 2016
年：2016
卷：46
期：Complete
页码：18-25
全文大小：1247 K

文摘

•: The analysis of prior thrombosis disclosed unbiased pro-thrombotic features in MPN.
•: Minor thrombocytosis showed a notable pro-thrombotic effect (hemostatic paradox).
•: Erythrocytosis had a pro-thrombotic effect also in MPN other than PV.
•: Leukocytosis, JAK2 mutation, and CVRFs confirmed their pro-thrombotic value.

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