Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

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• 作者：Anna Segerman¹ ; ³ ; ^{anna.segerman@igp.uu.se} ; Mia Niklasson¹ ; Caroline Haglund² ; Tobias Bergströ ; m¹ ; Malin Jarvius² ; Yuan Xie¹ ; Ann Westermark¹ ; Demet Sö ; nmez¹ ; ⁶ ; Annika Hermansson¹ ; Marianne Kastemar¹ ; Zeinab Naimaie-Ali¹ ; Frida Nyberg² ; Malin Berglund² ; Magnus Sundströ ; m¹ ; Gö ; ran Hesselager⁴ ; Lene Uhrbom¹ ; Mats Gustafsson² ; Rolf Larsson² ; Må ; rten Fryknä ; s² ; Bo Segerman¹ ; ⁵ ; ^{bo.segerman@igp.uu.se} ; Bengt Westermark¹ ; ⁷ ; ^{bengt.westermark@igp.uu.se}
• 关键词：glioma ; intratumoral ; heterogeneity ; clones ; proneural ; mesenchymal ; transition ; resistant ; drug ; radiation
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：13 December 2016
• 年：2016
• 卷：17
• 期：11
• 页码：2994-3009
• 全文大小：8934 K
• 卷排序：17

文摘

Intratumoral heterogeneity of glioblastoma is captured by clone libraries Pre-existing multitherapy-resistant glioma cells have a mesenchymal character A gradient of therapy resistance is linked to a proneural-mesenchymal axis Therapy resistance is associated with an altered DNA methylation pattern