RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment

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RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment

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作者：Iliya Lefterov^a ; ^{iliyal@pitt.edu" class="auth_mail" title="E-mail the corresponding author} ; Jonathan Schug^b ; ^c ; Anais Mounier^a ; Kyong Nyon Nam^a ; Nicholas F. Fitz^a ; Radosveta Koldamova^a ; ^{radak@pitt.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Alzheimer's disease ; APP/PS1 transgenic mice ; mRNA-seq ; ChIP ; RXR ; Bexarotene ; Trem2 ; Tyrobp ; Aβ phagocytosis
刊名：Neurobiology of Disease
出版年：2015
出版时间：October 2015
年：2015
卷：82
期：Complete
页码：132-140
全文大小：1065 K

文摘

•: We treated APP/PS1 mice with bexarotene — a specific RXR agonist in clinical use.
•: The response to bexarotene treatment involves genes relevant to inflammation.
•: Up-regulation of Trem2, Tyrobp, C1q complex and Apoe could explain the effect.
•: Ligand activation of RXR may have a therapeutic effect in early stages of AD.

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