Panoptic clinical review of the current and future treatment of relapsed/refractory T-cell lymphomas: Cutaneous T-cell lymphomas

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Panoptic clinical review of the current and future treatment of relapsed/refractory T-cell lymphomas: Cutaneous T-cell lymphomas

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作者：Pier Luigi Zinzani^a ; ^{pierluigi.zinzani@unibo.it" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Vijayveer Bonthapally^b ; Dirk Huebner^c ; Richard Lutes^c ; Andy Chi^d ; Stefano Pileri^e ; ^f
关键词：Bexarotene ; Brentuximab vedotin ; Cutaneous T-cell lymphoma ; Mycosis fungoides ; Romidepsin ; Sé ; zary syndrome ; Vorinostat
刊名：Critical Reviews in Oncology and Hematology
出版年：2016
出版时间：March 2016
年：2016
卷：99
期：Complete
页码：228-240
全文大小：891 K

文摘

•: Many patients with CTCLs, including MF and SS, develop relapsed/refractory disease.
•: Three systemic drugs are specifically approved for use in relapsed/refractory CTCL.
•: Durable responses are possible with HDAC inhibitors, but the ORR is usually <35%.
•: Promising novel agents include brentuximab vedotin, E777, and mogamulizumab.

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