Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Opening Hours
Collections
Help Via Email

Electronic Information Resources

Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1

详细信息查看全文

作者：Masaya Tachibana ; Mitsuru Shinohara ; Yu Yamazaki ; Chia-Chen Liu ; Justin Rogers ; Guojun Bu ; ^{bu.guojun@mayo.edu" class="auth_mail" title="E-mail the corresponding author} ; Takahisa Kanekiyo ; ^{kanekiyo.takahisa@mayo.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：ABCA1 ; ATP binding cassette ; subfamily A ; member 1 ; AD ; Alzheimer's disease ; Aβ ; amyloid-β ; apoE ; apolipoprotein E ; Bex ; bexarotene ; ELISA ; enzyme-linked immune-sorbent assay ; GluR1 ; glutamate receptor 1 ; LRP1 ; low-density lipoprotein receptor-related protein 1 ; LXR ; liver X receptor ; NR1 ; N-methyl-d-aspartate receptor NR1 subunit ; RXR ; retinoid X receptor ; TR ; targeted replacement
刊名：Experimental Neurology
出版年：2016
出版时间：March 2016
年：2016
卷：277
期：Complete
页码：1-9
全文大小：1794 K

文摘

•: An RXR agonist bexarotene significantly increases brain apoE levels in aged mice.
•: Bexarotene administration rescues aging-related synapse loss.
•: Neuronal apoE receptor LRP1 is required for the beneficial effects of bexarotene on synapses.
•: Severe hepatic dysfunctions were observed upon bexarotene treatment in aged mice.

NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.