Lack of support for bexarotene as a treatment for Alzheimer's disease

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Lack of support for bexarotene as a treatment for Alzheimer's disease

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作者：Eugene O'Hare^a ; ^{e.ohare@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Ross Jeggo^b ; ^{r.jeggo@neurosolutionsltd.com" class="auth_mail" title="E-mail the corresponding author} ; Eun-Mee Kim^c ; ^{e.kim@ulster.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Bridgeen Barbour^a ; ^{bmcmahon09@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Jean-Sebastien Walczak^d ; ^{jswalczak@cerebrasol.com" class="auth_mail" title="E-mail the corresponding author} ; Philip Palmer^a ; ^{ppalmer01@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Taylor Lyons^a ; ^{tlyons03@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Deaglan Page^a ; ^{d.page@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Donncha Hanna^a ; ^{donncha.hanna@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Jolyon R. Meara^e ; ^{jolyon.meara@wales.nhs.uk" class="auth_mail" title="E-mail the corresponding author} ; David Spanswick^b ; ^d ; ^f ; ^{david.spanswick@monash.edu" class="auth_mail" title="E-mail the corresponding author} ; Jian-Ping Guo^g ; Edith G. McGeer^g ; Patrick L. McGeer^g ; ^{mcgeerpl@mail.ubc.ca" class="auth_mail" title="E-mail the corresponding author} ; Peter Hobson^e ; ^{peter.hobson@wales.nhs.uk" class="auth_mail" title="E-mail the corresponding author}
关键词：Bexarotene ; Alzheimer's disease ; Beta-amyloid ; Oligomers ; Synaptic transmission ; Behavior
刊名：Neuropharmacology
出版年：2016
出版时间：January 2016
年：2016
卷：100
期：Complete
页码：124-130
全文大小：1309 K

文摘

•: Amyloid-尾 is a central endogenous pathogen in Alzheimer's disease (AD).
•: Soluble A尾 oligomers are the major cause of synaptotoxicity/neurodegeneration in AD.
•: Bexarotene administration has been proposed as a potential treatment for AD.
•: Bexarotene administration had no effects on histology or electrophysiology.
•: Bexarotene administration had no effects on A尾-induced cognitive decline.