Brown Adipogenic Reprogramming Induced by a Small Molecule

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• 作者：Baoming Nie¹ ; ⁸ ; Tao Nie² ; ³ ; ⁴ ; ⁸ ; Xiaoyan Hui⁵ ; ⁸ ; Ping Gu⁶ ; Liufeng Mao³ ; ⁴ ; Kuai Li³ ; ⁴ ; Ran Yuan³ ; ⁴ ; Jiashun Zheng⁷ ; Haixia Wang¹ ; Ke Li¹ ; Shibing Tang¹ ; Yu Zhang¹ ; Tao Xu¹ ; Aimin Xu⁵ ; Donghai Wu³ ; ⁴ ; ^{wu_donghai@gibh.ac.cn} ; Sheng Ding¹ ; ⁹ ; ^{sheng.ding@gladstone.ucsf.edu}
• 关键词：bexarotene ; RXR ; brown adipocyte ; C2C12 ; adipogenesis
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：624-635
• 全文大小：3781 K
• 卷排序：18

文摘

Bexarotene was identified as a hit to convert myoblasts into brown-like adipocytes Bexarotene induces brown reprogramming via RXR PRDM16 is required for bexarotene/RXR-induced browning Oral bexarotene treatment enhances BAT mass and function in mice