Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma

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• 作者：Jong Bong Lee^a ; Atheer Zgair^a ; ^b ; Tae Hwan Kim^c ; Min Gi Kim^c ; Sun Dong Yoo^c ; Peter M. Fischer^a ; Pavel Gershkovich^a ; ^{Pavel.Gershkovich@nottingham.ac.uk}
• 关键词：Bexarotene ; HPLC-UV ; Preclinical pharmacokinetics ; Rat plasma ; Human plasma ; Mouse plasma
• 刊名：Journal of Chromatography B
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：1040
• 期：Complete
• 页码：73-80
• 全文大小：1408 K
• 卷排序：1040

文摘

Bioanalytical method for determination of bexarotene in rat plasma was developed. Full validation was performed including samples stability studies. Applicability was demonstrated by pharmacokinetic study in rats. The suitability of the method was also assessed for human and mouse plasma.