Bexarotene protects against traumatic brain injury in mice partially through apolipoprotein E

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• 作者：Jianjun Zhong^a ; Chongjie Cheng^a ; Han Liu^a ; Zhijian Huang^a ; Yue Wu^a ; Zhipeng Teng^a ; Junchi He^a ; Hongrong Zhang^a ; Jinchuan Wu^a ; Fang Cao^b ; Li Jiang^a ; ; Xiaochuan Sun^a ;
• 关键词：BBB ; blood&ndash ; brain barrier ; CNS ; central nervous system ; CCI ; controlled cortical impact ; IOD ; integral optical density ; LXR ; liver X receptors ; PBS ; phosphate-buffered saline ; RXR ; retinoid X receptors ; TBI ; traumatic brain injury
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：343
• 期：Complete
• 页码：434-448
• 全文大小：3829 K
• 卷排序：343

文摘

Bexarotene improves motor function and spatial memory following traumatic brain injury in mice. Bexarotene inhibits inflammatory response and reduces cell apoptosis around injured site following traumatic brain injury. Bexarotene’s neuroprotective effects on traumatic brain injury perhaps closely related to ApoE.