Selective preservation of cholinergic MeCP2 rescues specific Rett-syndrome-like phenotypes in MeCP2^stop mice

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• 作者：Huanhuan Zhou^a ; Wei Wu^a ; Ying Zhang^b ; Haiyang He^b ; Zhefeng Yuan^c ; Zhiwei Zhu^a ; Zhengyan Zhao^a ; ^{zzy_ees@163.com}
• 关键词：RTT ; Rett syndrome ; MeCP2 ; methyl CpG-binding protein 2 ; Chat ; choline acetyltrasferase ; MS ; medial septal nucleus ; VDB ; nucleus of the vertical limb of the diagonal band ; HDB ; nucleus of the horizontal limb of the diagonal band ; PPTg ; primarily pedunculopontine tegmental nucleus ; LDT ; laterodorsal tegmental nucleus ; PPI ; prepulse inhibition
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：30 March 2017
• 年：2017
• 卷：322
• 期：part_PA
• 页码：51-59
• 全文大小：1124 K
• 卷排序：322

文摘

Preserving cholinergic MeCP2 reverses RTT-like hypolocomotion. Cholinergic MeCP2 preservation rescues RTT-like anxiety behavior in mice. Cholinergic MeCP2 couldn’t rescue the hypersocial abnormality of MeCP2-null mice. Cholinergic MeCP2 couldn’t significantly improve RTT-like poor general condition. The rescue effect might not be mediated by the whole brain Chat level alteration.