HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL

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HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL

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作者：Anouk Regeling^a ; ^{anoukregeling@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Floris Imhann^a ; ^{f.imhann@rug.nl" class="auth_mail" title="E-mail the corresponding author} ; Haukeline H. Volders^b ; ^{haukeline@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Tjasso Blokzijl^b ; ^{t.blokzijl@umcg.nl" class="auth_mail" title="E-mail the corresponding author} ; Vincent W. Bloks^c ; ^{v.w.bloks@umcg.nl" class="auth_mail" title="E-mail the corresponding author} ; Rinse K. Weersma^a ; ^{r.k.weersma@umcg.nl" class="auth_mail" title="E-mail the corresponding author} ; Gerard Dijkstra^a ; ¹ ; ^{gerard.dijkstra@umcg.nl" class="auth_mail" title="E-mail the corresponding author} ; Klaas Nico Faber^a ; ¹ ; ^{k.n.faber@umcg.nl" class="auth_mail" title="E-mail the corresponding author}
关键词：Ulcerative colitis ; Cigarette smoke ; Intestinal epithelium ; Heat shock protein A6 ; Apoptosis
刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年：2016
出版时间：April 2016
年：2016
卷：1862
期：4
页码：788-796
全文大小：1349 K

文摘

•: A mechanism is proposed how cigarette smoke protects against ulcerative colitis.
•: Cigarette smoke induces cytoprotective heat shock proteins, in particular HSPA6.
•: HSPA6, unique for large mammals, is highly expressed in human intestinal epithelia.
•: An ulcerative colitis susceptibility locus is associated with reduced HSPA6 expression.
•: HSPA6 physically interacts and enhances levels of anti-apoptotic Bcl-XL.