Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning

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• 作者：Marco Pignatelli¹ ; George Kwabena Essien Umanah⁴ ; ⁵ ; Sissi Palma Ribeiro¹ ; Rong Chen⁴ ; ⁵ ; Senthilkumar Senthil Karuppagounder⁴ ; ⁵ ; Hau-Jie Yau¹ ; Stephen Eacker⁴ ; ⁵ ; Valina Lynn Dawson² ; ⁴ ; ⁵ ; ⁷ ; Ted Murray Dawson² ; ⁴ ; ⁵ ; ⁶ ; Antonello Bonci¹ ; ² ; ³ ; ⁸ ; ^{antonello.bonci@nih.gov}
• 关键词：dopamine ; fear ; memory ; synaptic plasticity
• 刊名：Neuron
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：93
• 期：2
• 页码：425-440
• 全文大小：5116 K
• 卷排序：93

文摘

Stress priming enhances fear learning by engaging VTA synaptic plasticity Increase of AMPA receptor surface expression and function onto ThoraseDAKO neurons Impair induction and expression of LTD and LTP on ThoraseDAKO neurons Ab initio synaptic plasticity onto DAT+ neurons increases associative fear learning