State-Dependent Mechanisms of LTP Expression Revealed by Optical Quantal Analysis

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• 作者：Bonnie Ward ; Lindsay McGuinness ; Colin  ; J. Akerman ; Alan Fine ; Tim V.P. Bliss ; Nigel J. Emptage
• 刊名：Neuron
• 出版年：2006
• 出版时间：22 November 2006
• 年：2006
• 卷：52
• 期：4
• 页码：649-661
• 全文大小：1049 K

文摘

Summary

The expression mechanism of long-term potentiation (LTP) remains controversial. Here we combine electrophysiology and Ca²⁺ imaging to examine the role of silent synapses in LTP expression. Induction of LTP fails to change p_r at these synapses but instead mediates an unmasking process that is sensitive to the inhibition of postsynaptic membrane fusion. Once unmasked, however, further potentiation of formerly silent synapses leads to an increase in p_r. The state of the synapse thus determines how LTP is expressed.