BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer

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• 作者：Carlos Ló ; pez-Garcí ; ap>1p> ; Laurent Sansregretp>1p> ; Enric Domingop>5p>p> ; p>p>6p> ; Nicholas McGranahanp>1p>p> ; p>p>7p> ; Sebastijan Hoborp>1p> ; Nicolai Juul Birkbakp>1p>p> ; p>p>7p> ; Stuart Horswellp>2p> ; Eva Grö ; nroosp>1p> ; Francesco Faverop>1p>p> ; p>p>8p> ; Andrew J. Rowanp>1p> ; Nicholas Matthewsp>4p> ; Sharmin Begump>4p> ; Benjamin Phillimorep>4p> ; Rebecca Burrellp>1p> ; Dahmane Oukrifp>9p> ; Bradley Spencer-Denep>3p> ; Michal Kovacp>5p> ; Gordon Stampp>3p> ; Aengus Stewartp>2p> ; Havard Danielsenp>10p> ; Marco Novellip>9p> ; Ian Tomlinsonp>5p> ; Charles Swantonp>1p>p> ; p>p>7p>p> ; p>p>11p>p> ; p>p>charles.swanton@crick.ac.ukp>
• 关键词：aneuploidy tolerance ; chromosomal instability ; BCL9L ; caspase-2 ; p53 ; intratumor heterogeneity ; chromosome segregation errors ; mitotic checkpoint ; BID ; colorectal cancer evolution
• 刊名：Cancer Cell
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：79-93
• 全文大小：2665 K
• 卷排序：31

文摘

Loss-of-function alterations in BCL9L are frequent in aneuploid CRC BCL9L dysfunction drives aneuploidy tolerance by reducing levels of caspase-2 Caspase-2 activation following aneuploidy results in MDM2 and BID cleavage p53 stabilization after chromosome missegregation is regulated by caspase-2