Bradykinin promotes migration and invasion of hepatocellular carcinoma cells through TRPM7 and MMP2

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Bradykinin promotes migration and invasion of hepatocellular carcinoma cells through TRPM7 and MMP2

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作者：Yijie Chen^a ; Yang Yu^a ; Shuya Sun^a ; Zhaotong Wang^b ; Peiqing Liu^a ; ^c ; Shenglan Liu^a ; Jianmin Jiang^a ; ^{lssjjm@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：HCC ; hepatocellular carcinoma ; BK ; bradykinin ; NMHC-IIA ; non-muscle myosin IIA heavy chain ; BDKRB1/B1R ; bradykinin receptor B1 ; BDKRB2/B2R ; bradykinin receptor B2 ; LDBK ; Lys-des[Arg9]-bradykinin ; TMPS ; triple membrane passing signal ; NM-IIA ; non-muscle myosin IIA ; AMC ; 7-Amido-4-Methylcoumarin ; HRP ; Horseradish Peroxidase ; TBS-T ; Tris buffered saline-Tween 20 ; ECL ; electrochemiluminescence ; NC ; negative control ; siTRPM7 ; small interference RNA of TRPM7 ; CAPN1 ; calpain 1/μ-calpain ; CAPN2 ; calpain
刊名：Experimental Cell Research
出版年：2016
出版时间：15 November 2016
年：2016
卷：349
期：1
页码：68-76
全文大小：1027 K

文摘

•: Bradykinin promoted migration and invasion of HepG2 cells through TRPM7 and MMP2.
•: The effect of Bradykinin on NMHC-IIA Ser-1943 was similar to EGF's.
•: Ser-1943 could be an overlooked phosphorylation site on NMHC-IIA for TRPM7.
•: Both NM-IIA and calpains were important for migrating cancer cells.
•: Src regulated the invadopodia formation and MMP2 secretion of HepG2 cells.

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