Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status
文摘
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<p id="p0010">Dormant stem cells (d-ISCs) contribute to intestinal regeneration after fastingp>
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<p id="p0015">Decreased nutrients lead to transient PTEN inhibition and increased d-ISC numbersp>
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<p id="p0020">Cell-autonomous activation of PI3K→AKT→mTORC1 signaling mediates d-ISC responsep>
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<p id="p0025">PTEN is essential for d-ISC maintenance and intestinal regenerationp>
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