The budding yeast orthologue of Parkinson's disease-associated DJ-1 is a multi-stress response protein protecting cells against toxic glycolytic products

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• 作者：Urszula Natkańska ; Adrianna Skoneczna ; Marzena Sieńko ; Marek Skoneczny ; ^{kicia@ibb.waw.pl}
• 关键词：TF ; transcription factor
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1864
• 期：1
• 页码：39-50
• 全文大小：1562 K
• 卷排序：1864

文摘

Hsp31p is a budding yeast orthologue of Parkinson's disease-associated DJ-1 protein. It is a multi-stress response protein controlled by multiple TFs. It protects cells against methylglyoxal and other toxic products of glycolysis. It may be crucial for budding yeast survival in methylglyoxal-rich natural niches.