Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases

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• 作者：Jacinta Bustamante ; Sté ; phanie Boisson-Dupuis ; Emmanuelle Jouanguy ; Capucine Picard ; Anne Puel ; Laurent Abel ; Jean-Laurent Casanova
• 关键词：Homocysteine ; Homocysteine nanosystem ; Cluster ; Dielectric loss ; Diffusion coefficient ; Molecular dynamics (MD) simulation
• 刊名：Current Opinion in Immunology
• 出版年：2008
• 出版时间：February 2008
• 年：2008
• 卷：20
• 期：1
• 页码：39-48
• 全文大小：666 K

文摘

Excessive of homocysteine in the human body is recently considered as a factor increasing the risk of the cardiovascular system diseases. The nanosystem composed of finite number of homocysteine molecules (n = 20, 50 and 80) have been studied by MD technique. Several physical quantities of homocysteine nanosystem have been calculated as a function of temperature and a number of molecules in homocysteine cluster. The total dipole moment autocorrelation function and dielectric loss of the cluster have been also obtained.