ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch

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ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch

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作者：Steven Zhao¹ ; ² ; ⁷ ; AnnMarie Torres¹ ; ² ; ⁷ ; Ryan A. Henry⁵ ; Sophie Trefely¹ ; ² ; ⁴ ; Martina Wallace⁶ ; Joyce V. Lee¹ ; ² ; Alessandro Carrer¹ ; ² ; Arjun Sengupta³ ; Sydney L. Campbell¹ ; ² ; Yin-Ming Kuo⁵ ; Alexander J. Frey⁴ ; Noah Meurs⁶ ; John M. Viola¹ ; ² ; Ian A. Blair³ ; Aalim M. Weljie³ ; Christian M. Metallo⁶ ; Nathaniel W. Snyder⁴ ; Andrew J. Andrews⁵ ; Kathryn E. Wellen¹ ; ² ; ⁸ ; ^{wellenk@exchange.upenn.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：ACLY ; ACSS2 ; acetyl-CoA ; acetate ; acetylation ; fatty acid synthesis ; adipose tissue ; metabolism ; metabolic flexibility
刊名：Cell Reports
出版年：2016
出版时间：18 October 2016
年：2016
卷：17
期：4
页码：1037-1052
全文大小：4798 K

文摘

•: ACSS2 is upregulated upon genetic deletion of Acly in vitro and in vivo
•: Acetate sustains viability in Acly-deficient MEFs, but proliferation is impaired
•: Low levels of acetate can supply abundant acetyl-CoA in the absence of ACLY
•: Acetate partially rescues lipogenesis and histone acetylation in ACLY deficiency

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