Inflammatory proteases in chronic otitis media externa

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• 作者：Antonelli ; Patrick J. ; Schultz ; Gregory S. ; Cantwell ; John S. ; Sundin ; David J. ; Pemberton ; Philip A. ; et. al.
• 刊名：Otolaryngology - Head and Neck Surgery
• 出版年：2004
• 出版时间：August, 2004
• 年：2004
• 卷：131
• 期：2
• 页码：P262
• 全文大小：36.1 K

文摘

Objectives: Proteases are known to contribute to the pathogenesis of chronic inflammatory skin conditions, such as atopic dermatitis and psoriasis. Inhibition of these proteases has shown promise in the treatment of these skin conditions. The purpose of this study was to measure the matrix metalloproteinases (MMP) and human neutrophil elastase (HNE) activities in chronic otitis externa (COE) and to determine if addition of the serine protease inhibitor, recombinant alpha 1-antitrypsin (rAAT), and the MMP inhibitor, ilomastat, might reduce these protease activities.