Serum levels of C-terminal agrin fragment (CAF) are associated with sarcopenia in older multimorbid community-dwellers: Results from the ilSIRENTE study

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Serum levels of C-terminal agrin fragment (CAF) are associated with sarcopenia in older multimorbid community-dwellers: Results from the ilSIRENTE study

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作者：Francesco Landi^a ; ^{francesco.landi@rm.unicatt.it" class="auth_mail" title="E-mail the corresponding author} ; Riccardo Calvani^a ; Maria Lorenzi^a ; Anna Maria Martone^a ; Matteo Tosato^a ; Michael Drey^b ; Emanuela D'Angelo^a ; Ettore Capoluongo^c ; Andrea Russo^d ; Roberto Bernabei^a ; Graziano Onder^a ; Emanuele Marzetti^a ; ^{emarzetti@live.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Aging ; Frailty ; Biomarkers ; Skeletal muscle ; Muscle wasting ; Functional impairment ; Physical performance ; Co-morbidity ; Anthropometry ; Neuromuscular junction ; Mid-arm muscle circumference ; Handgrip ; Gait speed ; Renal failure
刊名：Experimental Gerontology
出版年：2016
出版时间：15 June 2016
年：2016
卷：79
期：Complete
页码：31-36
全文大小：447 K

文摘

•: Biomarkers for sarcopenia are needed to screen for the condition in the community.
•: C-terminal agrin fragment (CAF) is a promising biomarker measureable in the serum.
•: Serum CAF is associated with sarcopenia in older, multimorbid community-dwellers.
•: The association between CAF and sarcopenia is independent of multiple confounders.
•: CAF is associated with all the domains defining sarcopenia according to the EWGSOP.