A convenient route towards deoxygalactosyl-functionalised ortho-carbaborane: Synthesis of a building block for peptide conjugation

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作者：René ; Frank ; Evamarie Hey-Hawkins ; ^{hey@uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author}
关键词：Carbaboranes ; Carboranes ; Monosubstitution ; Galactose ; Water solubility ; Peptide ; Bioconjugation
刊名：Journal of Organometallic Chemistry
出版年：2015
出版时间：1 December 2015
年：2015
卷：798
期：part_P1
页码：46-50
全文大小：582 K

文摘

•: ortho-Carbaborane (1,2-closo-C₂B₁₀H₁₂) was asymmetrically functionalised with a deoxy-galactosyl and carboxyl ethyl moiety.
•: The key intermediate Deoxygalactose-functionalised ortho-carbaborane was synthesised by two independent synthetic routes in similar yield.
•: The direct synthesis of the key intermediate gave comparable (or better) yield than the recommended silyl protection.
•: The carboxyl group was formed under mild conditions employing ruthenium catalysts and periodate as a gentle oxidant.