Claudin-5, -7, and -18 suppress proliferation mediated by inhibition of phosphorylation of Akt in human lung squamous cell carcinoma

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• 作者：Risa Akizuki ; Shun Shimobaba ; Toshiyuki Matsunaga ; Satoshi Endo ; Akira Ikari ; ^{ikari@gifu-pu.ac.jp}
• 关键词：CLDNs ; claudins ; CA ; constitutively active ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; DN ; dominant negative ; EGFR ; epidermal growth factor receptor ; ERK ; extracellular signal-regulated kinase ; LDH ; lactate dehydrogenase ; MAP ; mitogen-activated protein ; NSCLC ; non-small cell lung cancer ; PCR ; polymerase chain reaction ; PDK1 ; 3-phosphoinositide-dependent protein kinase-1 ; PI ; propidium iodide ; PI3K ; phosphatidylinositol-3 kinase ; PKA ; protein kinase A ; SCLC ; small cell lung cancer ; SDS-PAGE ; sodi
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1864
• 期：2
• 页码：293-302
• 全文大小：1488 K
• 卷排序：1864

文摘

Claudin-3-5, 7, and 18 are decreased in human lung squamous carcinoma. Claudin-5, 7, and 18 individually and additively inhibit proliferation of squamous carcinoma cells. Claudin-5, 7, and 18 inhibit phosphorylation of Akt. Claudin-5, 7, and 18 bind to Akt and decrease its nuclear localization. Loss of claudin-5, 7, and 18 expression may induce abnormal proliferation in lung squamous carcinoma cells.