Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics

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• 作者：Kristopher A. Sarosiek¹ ; ² ; ¹² ; Cameron Fraser¹ ; Nathiya Muthalagu³ ; Patrick D. Bhola¹ ; ² ; Weiting Chang² ; ⁴ ; Samuel K. McBrayer¹ ; ² ; Adam Cantlon² ; ⁴ ; Sudeshna Fisch² ; ⁴ ; Gail Golomb-Mello⁵ ; Jeremy A. Ryan¹ ; ² ; Jing Deng¹ ; ² ; Brian Jian⁶ ; Chris Corbett⁷ ; Marti Goldenberg⁷ ; Joseph R. Madsen² ; ⁷ ; Ronglih Liao² ; ⁴ ; Dominic Walsh² ; ⁴ ; John Sedivy⁵ ; Daniel J. Murphy³ ; ⁸ ; Daniel Ruben Carrasco¹ ; ² ; Shenandoah Robinson² ; ⁷ ; Javid Moslehi⁹ ; ¹⁰ ; ¹¹ ; Anthony Letai¹ ; ² ; ¹³ ; ^{anthony_letai@dfci.harvard.edu}
• 关键词：apoptosis ; radiosensitivity ; chemosensitivity ; neurotoxicity ; cardiotoxicity ; side effects of chemotherapy ; side effects of radiation therapy ; cell death regulation ; c-Myc ; pediatric cancer
• 刊名：Cancer Cell
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：142-156
• 全文大小：5138 K
• 卷排序：31

文摘

Cells within healthy adult brain, heart, and kidneys are apoptosis refractory Early in life, brain, heart, and kidney cells are primed for apoptosis Dynamic regulation of apoptosis affects cell fate in response to genotoxic damage The apoptosis pathway is modulated by c-Myc, linking cellular growth with death