PCV13-vaccinated children still carrying PCV13 additional serotypes show similar carriage density to a control group of PCV7-vaccinated children

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• 作者：Ron Dagan^a ; ^{rdagan@bgu.ac.il} ; Christine Juergens^b ; ^{Christine.Juergens@pfizer.com} ; James Trammel^c ; ^{james.trammel@inventivhealth.com} ; Scott Patterson^d ; ^{Scott.Patterson@Pfizer.com} ; David Greenberg^a ; ^e ; ^{dudi@bgu.ac.il} ; Noga Givon-Lavi^a ; ^e ; ^{givon@bgu.ac.il} ; Nurith Porat^a ; ^e ; ^{npurat@bgu.ac.il} ; William C. Gruber^f ; ^{Bill.Gruber@Pfizer.com} ; Daniel A. Scott^d ; ^{Dan.scott@Pfizer.com}
• 关键词：Streptococcus pneumoniae ; Pneumococcal conjugate vaccine ; Nasopharyngeal carriage ; Density ; Indirect protection
• 刊名：Vaccine
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：35
• 期：6
• 页码：945-950
• 全文大小：298 K
• 卷排序：35

文摘

Limited evidence suggests that PCVs impact vaccine-type carriage density. This double-blind PCV study suggests no impact on vaccine-type carriage density. PCV13 may affect carriage by reducing carrier number but not vaccine-type density. Carriage density may not impact herd effects.