N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids

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N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids

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作者：Tomá ; s Herraiz ^{tomas.herraiz@csic.es" class="auth_mail" title="E-mail the corresponding author}
关键词：1-methyl-4-phenyl-1 ; 2 ; 3 ; 6-tetrahydropyridine (MPTP) ; 1-methyl-4-phenylpyridinium cation (MPP+) ; Paraquat ; β-carboline ; Tetrahydroisoquinoline ; Neurotoxins ; Neuroprotectants ; Parkinson's disease
刊名：Food and Chemical Toxicology
出版年：2016
出版时间：November 2016
年：2016
卷：97
期：Complete
页码：23-39
全文大小：1574 K

文摘

•: N-methyltetrahydropyridines (MPTP) and pyridinium cations (MPP⁺) are neurotoxins.
•: Paraquat, β-carbolines (βCs) and tetrahydroisoquinolines (TIQs) are structural analogues of MPTP/MPP⁺.
•: Paraquat is a neurotoxin that differs from MPTP/MPP⁺ and act by generation of ROS.
•: β-Carbolinium (βC⁺) and isoquinolinium (IQ⁺) cations are MPP⁺-like neurotoxins.
•: β-Carbolines and tetrahydroisoquinolines are neuroprotectant/neurorestorative agents.

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