Interruption of the transmission of Onchocerca volvulus in the Kashoya-Kitomi focus, western Uganda by long-term ivermectin treatment and elimination of the vector Simulium neavei by larviciding

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• 作者：T. Lakwo^a ; ^{tlakwo@gmail.com} ; R. Garms^b ; J. Wamani^c ; E.M. Tukahebwa^a ; E. Byamukama^d ; A.W. Onapa^e ; E. Tukesiga^f ; J. Katamanywa^g ; S. Begumisa^h ; P. Habomugishaⁱ ; D. Oguttu^a ; E. Byamukamaⁱ ; F. Richards^j ; T.R. Unnasch^k ; M. Katabarwa^j
• 关键词：Interruption ; Long-term treatment ; Ivermectin ; S. neavei ; Larviciding ; Onchocerca volvulus ; Uganda
• 刊名：Acta Tropica
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：128-136
• 全文大小：1463 K
• 卷排序：167

文摘

We describe the effect of combining annual and bi-annual ivermectin treatment with ground larviciding using temephos (Abate®EC500) against S. neavei in the interruption of onchocerciasis transmission. Epidemiological, entomological and serological assessments were performed. Significant reductions in mf prevalence, crab infestations and S. neavei adult catches were observed in the focus. Four IgG4 positive children subjected to O-150 PCR skin snip analysis were all negative. The data suggest that interruption of transmission of onchocerciasis has been achieved in the focus.