Interaction of antibodies against cytomegalovirus with heat-shock protein 60 in pathogenesis of atherosclerosis

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• 作者：Bason ; Caterina ; Corrocher ; Prof Roberto ; Lunardi ; Prof Claudio ; Puccetti ; Patrizia ; Olivieri ; Prof Oliviero ; et. al.
• 刊名：The Lancet
• 出版年：2003
• 出版时间：December 13, 2003
• 年：2003
• 卷：362
• 期：9400
• 页码：1971-1977
• 全文大小：478 K

文摘

Background Infections and autoimmunity have been implicated in the pathogenesis of atherosclerosis. Cytomegalovirus has been shown to contribute to the disease. Autoantibodies against human heat-shock protein (HSP) 60 are present in most atherosclerotic patients, and their titre correlates with disease severity, suggesting that anti-HSP60 might be implicated in disease pathogenesis. We postulated that cytomegalovirus infection might induce antibodies able to bind human HSP60 and to cause endothelial-cell damage.